MYELOID NEOPLASIA A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia
نویسندگان
چکیده
Cyrus Khandanpour,1-3 Christian Thiede,4 Peter J. M. Valk,5 Ehssan Sharif-Askari,1 Holger Nückel,3 Dietmar Lohmann,6 Bernhard Horsthemke,6 Winfried Siffert,7 Andreas Neubauer,8 Karl-Heinz Grzeschik,9 Clara D. Bloomfield,10 Guido Marcucci,10 Kati Maharry,10,11 Marilyn L. Slovak,12 Bert A. van der Reijden,13 Joop H. Jansen,13 Hans K. Schackert,14 Khashayar Afshar,1 Susanne Schnittger,15 Justine K. Peeters,5 Frank Kroschinsky,4 Gerhard Ehninger,4 Bob Lowenberg,5 Ulrich Dührsen,3 and Tarik Möröy1,2
منابع مشابه
A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia.
The GFI1 gene encodes a transcriptional repressor, which regulates myeloid differentiation. In the mouse, Gfi1 deficiency causes neutropenia and an accumulation of granulomonocytic precursor cells that is reminiscent of a myelodysplastic syndrome. We report here that a variant allele of GFI1 (GFI1(36N)) is associated with acute myeloid leukemia (AML) in white subjects with an odds ratio of 1.6 ...
متن کاملA variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia Short title: GFI1 allele in AML
Cyrus Khandanpour, Christian Thiede, Peter J.M. Valk, Ehssan Sharif-Askari, Holger Nückel, Dietmar Lohmann, Bernhard Horsthemke, Winfried Siffert, Andreas Neubauer, Karl-Heinz Grzeschik, Clara D. Bloomfield, Guido Marcucci, Kati Maharry, Marilyn L. Slovak, Bert A. van der Reijden, Joop H. Jansen, Hans K. Schackert, Khashayar Afshar, Susanne Schnittger, Justine K. Peeters, Frank Kroschinsky, Ger...
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The coding single nucleotide polymorphism GFI136N in the human gene growth factor independence 1 (GFI1) is present in 3%-7% of whites and increases the risk for acute myeloid leukemia (AML) by 60%. We show here that GFI136N, in contrast to GFI136S, lacks the ability to bind to the Gfi1 target gene that encodes the leukemia-associated transcription factor Hoxa9 and fails to initiate histone modi...
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